Death is usually the result of cardiac arrest or seizures. This is common in people who take too high of a dose or take cocaine that’s laced with fentanyl or other potent substances. In rare cases, cocaine may lead to sudden death after one use. Side effects that occur when taking coke for the first time include: From the cardiovascular system to the respiratory system, various functions of the body are heightened the first time doing coke. What happens when you take coke for the first time is marked by a rush of euphoria.Ĭocaine stimulates the CNS, creating not only a sensation of euphoria but also other side effects marked by rapid neural activity. This causes dopamine to accumulate in the synapse and sendĪn amplified signal to neurons. Afterward, another protein called a transporter takes the dopamine from the synapse and recycles it for further use.Ĭocaine interrupts this process by binding to the dopamine transporter, blocking the removal and reuptake of dopamine from the synapse. In this way, dopamine is used as a chemical messenger that’s carried from one neuron to another. In the synapse, dopamine binds to specialized proteins called dopamine receptors on the neighboring neuron. Normally, dopamine is released by a neuron into the gap between two neurons (called the synapse). In addition to reward, this region of the brain also regulates emotions and motivation. This area of the brain is usually reinforced naturally by stimuli like food and sex but can also be stimulated by drugs of abuse. What Does Cocaine Do to You the First Time?Ĭocaine works by activating the mesolimbic dopamine system, which is the brain’s reward pathway. Let’s look at the effects of doing cocaine for the first time and how quickly you can become addicted to it. Despite the short-lived high it produces, many people become curious enough about cocaine to use it, often without understanding its risks. Today, however, cocaine is a Schedule II stimulant, meaning it is illegal to use recreationally in the United States. Cocaine has a long history in medicine and was originally used for pain relief before anesthesia was invented. It’s known by names like coke, blow, crack, and powder. Doing Cocaine for the First Time: Side Effects and RisksĬocaine is a central nervous system stimulant that can be snorted, smoked, or injected.
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